What Is FFPE Tissue Samples

  • April 7, 2021

Embedded FFPE, or fixed formaldehyde paraffin, is a method of storing tissue samples for long periods of time while preserving the morphological and cellular details of the tissue. Formalin paralyzes cellular metabolism, while paraffin closes tissue and reduces the rate of oxidation.

Many tissue samples are now stored using the FFPE method. FFPE network blocks are an important source for drug detection, biotechnology research, and retrospective genetic research. To get more information about the ffpe block storage visit http://www.geneticistinc.com

ffpe block storage

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FFPE tissue archives can be stored at room temperature for decades and are now an invaluable resource for retrospective studies to link molecular findings, clinical outcomes, and therapy. Currently, FFPE tissues are the most common source of archival material.

FFPE tissue is most often used in immunohistochemistry, where a section of tissue is attached to a slide. These are then bathed in a solution containing the antibodies so that they can bind to proteins and structures. 

This is important for the study of diseases such as cancer and Alzheimer's. Therefore, the FFPE network is of great importance in the following areas: oncology, hematology, and immunology.

When the hospital pathologist examines the biopsy obtained from the patient, multiple biopsy samples are filed for a second opinion. Donated human tissue or collected animal samples can also be stored using the FFPE method and archived for later inspection.

These archives are also known as biobanks and can be developed in dispensaries, universities, or organizations that serve the research community.